Acute Respiratory Viral Serology Array

The Acute Respiratory Viral Serology (ARVS) Array is a multiplex assay for high-throughput, high-definition serological studies of 27 unique validated recombinant antigens interrogating 3 different viruses. These viruses and their subtypes include Coronaviruses (SARS-CoV-2, SARS-CoV, MERS-CoV, and 4 common-cold Coronaviruses), Influenza A (H3N2, H1N1, H7N9, H5N1), Influenza B (3 lineages), and Respiratory Syncytial Viruses A and B. The Coronaviruses have higher definition to interrogate the Spike Receptor Binding Domain (RBD), Spike S1, Spike S1 +S2, and Nucleocapsid proteins (varies by Coronavirus subtype). SARS-CoV-2 also includes the mutant D614G protein. The array is designed to determine the antibody profile in serum samples with applications in epidemiology and serosurveillance, vaccine development, and basic translational research.

Available as complete respiratory viral serology array and as a COVID-19 focus Array
Utilizes Adarza’s AIR technology for high sensitivity and multiplex

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Specifications:

Analytes:

Influenza A Wisconsin H3N2

The influenza viral Hemagglutinin (HA) protein is a homo trimer with a receptor binding pocket on the globular head of each monomer. It is derived from the H3N2 Influenza A Wisconsin-2005 origin.

Influenza A Wisconsin H3N2

Influenza A Texas H3N2

The influenza H3N2 HA1 subunit is a subunit of the viral Hemagglutinin (HA) protein. It is derived from the H3N2 Influenza A Texas-2012 origin.

Influenza A Texas H3N2

Influenza A California H1N1

The influenza viral Hemagglutinin (HA) protein is a homo trimer with a receptor binding pocket on the globular head of each monomer. It is derived from the H1N1 Influenza A California-2009 origin.

Influenza A California H1N1

Influenza A Beijing H1N1

The influenza H1N1 HA1 subunit is a subunit of the viral Hemagglutinin (HA) protein. It is derived from the H1N1 Influenza A Beijing-2009 origin.

Influenza A Beijing H1N1

Influenza A Shanghai H7N9

The influenza viral Hemagglutinin (HA) protein is a homo trimer with a receptor binding pocket on the globular head of each monomer. It is derived from the H7N9 Influenza A Shanghai-2013 origin.

Influenza A Shanghai H7N9

Influenza A Vietnam H5N1

The influenza H5N1 HA1 subunit is a subunit of the viral Hemagglutinin (HA) protein. It is derived from the H5N1 Influenza A Vietnam-2004 origin.

Influenza A Vietnam H5N1

Influenza B Massachusetts

The influenza B viral Hemagglutinin (HA) protein is a homo trimer with a receptor binding pocket on the globular head of each monomer. It is derived from the Influenza B Massachusetts-2010 origin.

Influenza B Massachusetts

Influenza B Phuket

The influenza B viral Hemagglutinin (HA) protein is a homo trimer with a receptor binding pocket on the globular head of each monomer. It is derived from the Influenza B Phuket-2013 origin.

Influenza B Phuket

Influenza B Malaysia

The influenza B viral Hemagglutinin (HA) protein is a homo trimer with a receptor binding pocket on the globular head of each monomer. It is derived from the Influenza B Malaysia-2013 origin.

Influenza B Malaysia

CoV-HKU1 S1

The spike (S) glycoprotein of coronaviruses consists of the S1, S2 regions. The S1 region, which is responsible for the initial attachment of the virus HcoV-HKU1 to the surafce of host cells, is specifically targeted.

CoV-HKU1 S1

CoV-229E S1 + S2

The spike (S) glycoprotein of coronaviruses consists of the S1, S2 regions. The S1 region is responsible for the initial attachment of the virus HcoV-229E to the surface of host cells and the S2 region is responsible for membrane fusion that triggers the entry of the virus into host cells. Both the S1 and S2 region of HCoV-229E strain are specifically targeted.

CoV-229E S1 + S2

CoV-OC43 S1+ S2

The spike (S) glycoprotein of coronaviruses consists of the S1, S2 regions. The S1 region is responsible for the initial attachment of the virus HcoV-OC43 to the surface of host cells and the S2 region is responsible for membrane fusion that triggers the entry of the virus into host cells. Both the S1 and S2 region of HCoV-OC43 strain are specifically targeted.

CoV-OC43 S1+ S2

CoV-NL63 S1

The spike (S) glycoprotein of coronaviruses consists of the S1, S2, and RBD regions. The S1 region of the strain HcoV-NL63 is specifically targeted.

CoV-NL63 S1

SARS-CoV-2 Spike RBD Mutation D614G

The spike (S) glycoprotein of coronaviruses consists of the S1, S2 regions. The S1 region, which is responsible for the initial attachment of the virus SARS-CoV-2 (COVID-19) mutant D614G to the surface of host cells, is specifically targeted.

SARS-CoV-2 Spike RBD Mutation D614G

SARS-CoV-2 S1

The spike (S) glycoprotein of coronaviruses consists of the S1, S2 regions. The S1 region, which is responsible for the initial attachment of the virus SARS-CoV-2 (COVID-19) to the surface of host cells, is specifically targeted.

SARS-CoV-2 S1

SARS-CoV-2 RBD

The spike (S) glycoprotein of coronaviruses consists of the S1, S2 regions. The S1 region is responsible for the initial attachment of the virus SARS-CoV-2 (COVID-19) to the surface of host cells and the S2 region is responsible for membrane fusion that triggers the entry of the virus into host cells. The S1 contains a receptor binding domain (RBD) and is critical in attachment of the virus to host cells. The RBD is specifically targeted.

SARS-CoV-2 RBD

SARS-CoV-2 Nucleocapsid

Coronaviruses are enveloped viruses with a positive-sense RNA genome and with a nucleocapsid of helical symmetry. Coronavirus N protein is required for coronavirus RNA synthesis, and has RNA chaperone activity that may be involved in template switch. This Nucleocapsid is from the SARS-CoV-2 (COVID-2019).

SARS-CoV-2 Nucleocapsid

SARS-CoV-2 S1 + S2

The spike (S) glycoprotein of coronaviruses consists of the S1, S2 regions. The S1 region is responsible for the initial attachment of the virus SARS-CoV-2 (COVID-19) to the surface of host cells and the S2 region is responsible for membrane fusion that triggers the entry of the virus into host cells. Both the S1 and S2 region of SARS-CoV-2 ECD mutant strain are specifically targeted.

SARS-CoV-2 S1 + S2

SARS-CoV-2 S2

The spike (S) glycoprotein of coronaviruses consists of the S1, S2 regions. The S2 region is responsible for membrane fusion that triggers the entry of the virus into host cells. A mutant of the S2 region of the strain SARS-CoV-2 (COVID-19) is specifically targeted.

SARS-CoV-2 S2

MERS-CoV S1

The spike (S) glycoprotein of coronaviruses consists of the S1, S2 regions. The S1 region, which is responsible for the initial attachment of the virus MERS-CoV is specifically targeted.

MERS-CoV S1

MERS-CoV RBD

The spike (S) glycoprotein of coronaviruses consists of the S1, S2 regions. The S1 region is responsible for the initial attachment of the virus MERS-CoV to the surface of host cells and the S2 region is responsible for membrane fusion that triggers the entry of the virus into host cells. The S1 contains a receptor binding domain (RBD) and is critical in attachment of the virus to host cells. The RBD is specifically targeted.

MERS-CoV RBD

MERS-CoV Nucleocapsid

SARS-CoV S1

The spike (S) glycoprotein of coronaviruses consists of the S1, S2 regions. The S1 region, which is responsible for the initial attachment of the virus SARS-CoV to the surafce of host cells, is specifically targeted.

SARS-CoV S1

SARS-CoV RBD

SARS-CoV Nucleocapsid

The spike (S) glycoprotein of coronaviruses consists of the S1, S2 regions. The S1 region, which is responsible for the initial attachment of the virus SARS-CoV to the surface of host cells, is specifically targeted.

SARS-CoV Nucleocapsid

RSV A G Protein

Human respiratory syncytial virus (HRSV) is the most common etiological agent of acute lower respiratory tract disease in infants and can cause repeated infections throughout life. HRSV has two major surface glycoproteins (G and F) that play important roles in the initial stages of the infectious cycle. The G protein mediates attachment of the virus to the host cell membrane by interacting with heparan sulfate, initiating the infection. Secreted glycoprotein G helps RSV escape antibody-dependent restriction of replication by acting as an antigen decoy and by modulating the activity of leukocytes bearing Fcgamma receptors.

RSV A G Protein

RSV B G Protein

Kit Contents

Reagent	Volume	Quantity	Storage
96 well consumable with biosensor array	N/A	1	4˚C
Clear Plate Seal	1	1	RT
Plate Lid	1	1	RT
Negative Control	100µl	1	4°C
Positive Control*	25µl	1	4°C
Assay Buffer	16ml	1	4˚C
ZIVA™ Wash Buffer (ZWB)	50ml of 20X	1	4˚C

*The positive control contains a mixture of antibodies that result in a positive response to the following antigens: SARS-CoV-2 RBD, SARs-CoV-2 S1, SARS-CoV-2 D614G, SARS-CoV RBD, MERS-CoV RBD, Influenza B Malaysia, Influenza B Phuket

Acute Respiratory Viral Serology Array

Acute Respiratory Viral Serology Array

Notify me when new assays are launched.

We're happy to help you complete our purchase.

To get started now, just give us a call at

1-314-925-7800

Or complete the form below.

Specifications:

Analytes:

Kit Contents

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SPECIFICATION SHEET

SPECIFICATION SHEET

SPECIFICATION SHEET

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